Gene Context and DNA rearrangements in the carbapenemase locus of division II strains of Bacteroides fragilis.
نویسندگان
چکیده
The cfiA gene is clustered in a bicistronic operon encoding an N-acetyltransferase and an O-acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and ISBf9. Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS942 at its promoter was a determinant for expression of carbapenemase activity.
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1. Thompson JS, Malamy MH. Sequencing the gene for an imipenem-cefoxitin hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL 2480 reveals strong similarity between CfiA and Bacillus cereus b-lactamase II. J Bacteriol 1990; 172: 2584–93. 2. Edwards R, Read PN. Expression of the carbapenemase gene (cfiA) in Bacteroides fragilis. J Antimicrob Chemother 2000; 46: 1009–12. 3. Andrews JM. Determi...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 53 6 شماره
صفحات -
تاریخ انتشار 2009